Antipyretic activity of methanol leaf extract of Magnolia nilagirica (Zenkar) figlar. in wistar albino rats

Antipyretic activity of methanol leaf extract of Magnolia nilagirica (Zenkar) figlar. in wistar albino rats

Author: 
Abdul Kaffoor, H., Arumugasamy, K., Sekar, T., Nantha Kumar, R. and Shalimol, A.
Abstract: 

The study was conducted to evaluate the antipyretic activity of methanolic leaf extract of M. nilagirica by using yeast-induced pyrexia method. The results revealed that the different doses of methanolic leaf extract showed the potential to lower the body temperature up to 2 hours, following its administration. The effect of extract on yeast-induced pyrexia rats showed the rectal temperature elevated to 39.76 ºC, 24 h after the subcutaneous injection of yeast suspension and it decreased to 36.43 ºC within 6 hours of leaf extract (100 mg/kg) treatment. The extract thus showed a significant antipyretic activity against the yeast-induced pyretic model.

Paper No: 
532