A mixture Uncariagambir Roxb (gambir) is often used by some communities in Indonesia and other countries in Southeast Asia and South Asia to treat inflammation and other treatments. Catechins as the main content of the gambir are allegedly powerful that have anti-inflammatory properties. The objective of this study was to determine the anti-inflamatory activity of catechins isolate of gambir on carrageen an induced paw edema in wistar male rats. Catechins of gambir were isolated by using partition method with ethyl acetate solvent. A total of 30 wistar male rats were divided into 5 groups. Tests of anti-inflammatory effects was done based on Winter's modified paw edema method. Rats were made to suffer inflammation by the injected with carrageenan 0.1 ml of 1 % (b/v) . The effect of paw edema in male rats was done 1 hour after administration of test preparation for 6 hours by using plethysmometer. A total of 3 groups were given catechins isolate per oral with a dose of 1 mg/kg,b.w, 10 mg/kg b.w and 100 mg/kg b.w respectively. Test preparations were suspended in Na-CMC 0,5 %. As positive control was used Na-diclofenac 5,14 mg/kg b.w and as negative control was used Na-CMC 0,5 %. Based on the results of statistical tests was obtained a dose of 100 mg / kg b.w gives the greatest anti-inflamatory effect, ie 59.19%. while for doses of 1 mg / kg, b.w and 10 mg / kg b.w also significantly different compared to negative controls (ρ≤0.05). The dose of 10 mg / kg b.w have same effect with dose 1% Na-diclofenac For anti-inflammatory.
