Background & Objective: The increase of pressure in addition to cornea pain and edema could result in ischemic optic neuropathy. Different drugs can be employed for cutting down the intraocular pressure. The aim of this study was assessment the effect of Apraclonidineversus timololin decreasing intra ocular pressure after laser capsulotomy. Methods and Materials: This is a double blind clinical trial study that has been done on 200 patients with posterior capsular opacity that had been candidate for laser capsulotomy, were evaluated through tonometry method. Then the patients were divided randomly into two groups and each group was treated by timolol or apraclonidine. Then their intra ocular pressure was recorded 3 and 24 hours after the operation. Collected data were analyzed by statistical methods in SPSS.16. Results: The mean age of patients in timolol group was 65.7±12.04 yearand in Apraclonidine group was 67.8±9.7 year. The mean intra ocular pressure in timolol group was 15±3.8 before, 13.9±4.6 three hours, and 12.6±2.6 mmHg 24 hours after the operation. The Mean intra ocular pressure in apraclonidine group was 14.7±3.8 before, 14.1±3.3 three hours, and 13.04±2.6 mmHg 24 hours after the operation. The effect of apraclonidine in decreasing intra ocular pressure was the same as timolol. Conclusion: Apraclonidine can be suggested as the chosen drug with minimal side effects, in patients undergone laser posterior capsulotomy.
