Background: The prevalence of depression in the world population is 4.4% and has implications for the emotional, social and physical functions of the individual. According to WHO, this was associated throughout 50 million years - life with disabilities 2015. Objective: Determine the association of social-labor and family disability with the status of referral and severity of depression at the beginning of treatment and three months later. Methodology: Observational, comparative, and longitudinal study in patients with depression. Functional disability was measured at the beginning with Sheehan Disability Scale and severity of depression with Hamilton Depression Rating Scale at the beginning and three months later. Statistical analysis with Chi-square, t student, U Mann-Whitney, odds ratios and confidence intervals at 95%. Results: 250 patients were included, those with HDRS >7 had 11.6 ± 8.6 disability versus 4.3 ± 5.2 of which obtained HDRS ≤ 7 (p < .001). 170 (79.4%) patients presented disability and their HDRS punctuation was 11.2 ± 5.7 at the baseline and 8.6 ± 5.1 at three months, while 44 (20.6%) patients did not present disability and had a SDS punctuation of 7.0 ± 4.3 at the baseline and 5.3 ± 3.8 at three months (p < .001). OR 3.7 CI 95% (1.9 – 7.5) y OR 3.1, CI 95% (1.5 – 6.6) with baseline and final measurements of the HDRS. Conclusions: Functional disability, perceived stress y social support, are associated with depression, its referral and degree of severity.
