Introduction: Knee osteoarthritis (OA) or gonarthrosis is a chronic disease with a high prevalence in the adult population, which causes a significant physical limitation, which directly impacts the quality of life of patients. Surgical treatment in patients diagnosed with OA has shown good results in pain management, as well as in improving the functional capacity and mobility of the patient. The objective of this study was to compare two post-stabilized joint replacement designs and thus evaluate which of the two offers better post-surgical results and reduces the probability of complications in patients at the Naval Medical Center (CEMENAV) with gonarthrosis postoperatively for joint replacement surgery, with a two-year follow-up. Materials and methods: This is a prospective, observational, analytical and cross-sectional comparative clinical trial; which consisted of the capture of 50 patients postoperatively for knee joint replacement surgery during the period 2014-2017 at CEMENAV. These patients were administered two measuring instruments (Womac and Koos questionnaires) to evaluate motor functional capacity before and after surgery, in order to compare both prostheses. Also, an evolution of the interface zones and other radiological data was performed by means of the Knee Society Total Knee Arthroplasty radiological evaluation system to determine prosthetic loosening in both joint replacement designs. Results: This study showed that there is a relationship between the type of joint replacement system and the postoperative results in terms of symptoms, pain, functionality and quality of life of the patients, which was reinforced by the better clinical and radiological results observed in group 1 compared to those in group 2. Conclusion: Patients with OA treated with the system in Group 1 showed better clinical and radiological results compared to those treated with the system in Group 2.