Background: The use of High voltage stimulation in patients with pressure ulcers is very important, and thus the scientific evidence for its effectiveness needs to be evaluated through a systematic review. Objective: To provide updated evidence-based guidance for High voltage stimulation effects on the healing of pressure ulcers. Data sources: Pub Med (Medline), Ovid, Physiotherapy Evidence Database (Pedro), Google scholar website, Cochrane Central Register of Controlled Trials, Electron library of Cairo University, Science direct website were searched from their earliest records up to December. Data extraction: Template was created to systematically code the demographic, methodological, and miscellaneous variables of each RCT. The Physiotherapy Evidence Database (Pedro) scale was used to evaluate the study quality. Data synthesis: Five studies included 200 participants in total. Best evidence synthesis was applied to summarize the outcomes, which were wound Surface Area (WSA), Wound tracing measures, Planimetry of Congruent. Conclusions: The current level of evidence to support the effectiveness of electric stimulation (High voltage stimulation) on pressure ulcers healing is strong. As according to this review there is support enough to use electric stimulation (High voltage stimulation) in treatment of pressure ulcers to reduce wound surface area (WSA) in different stages of pressure ulcers and accelerate their healing and decrease the mortality rate of a patient with pressure ulcers.
