The study explored gender and locus of control as a comparative study of adolescent substance abuse in Awka Metropolis. Total number of one hundred and fifty-three (153) secondary school students in Awka metropolis; served as participant for the study. 61 (39.9%) were females while 92 (60.1%) were boys. Simple random sampling technique was used to select the secondary schools and the participants. Their ages comprised 11 to 18 years with a mean age of 14.86 years and standard deviation of 2.28. Substance Craving Scale by Mazza (2004) and Levenson Multidimensional Locus of Control by Levenson (1973) were employed for data generation. Two by Two Factorial Designs and Two-way Analysis of Variance (ANOVA) statistic were adopted and three hypotheses were tested. The first hypothesis which stated there will be no significant difference between boys and girls on adolescent substance abuse in Awka metropolis and the second hypothesis which stated that there will be no significant difference between those that have external and internal locus of control on adolescent substance abuse in Awka metropolis were confirmed at p>.05. while the third hypothesis which stated that there will be no significant interaction effect between gender and locus of control on adolescent substance abuse in Awka metropolis was confirmed at p>.05. Implications and recommendations of the study were properly established in the study.
