The present study evaluated the antiemetic effects of midazolam an ondansetron for preventing post operative nausea and vomiting in middle ear surgeries. Material and Mehods: After attaining approval by ethical committee of the institute, 105 patients were randomly divided into three groups (35 patients of ASA I and II physical status in each group). Group M received 0.05mg/kg of midazolam diluted in 5 ml of normal saline IV, Group O received 0.15mg/kg of ondansetron diluted in 5 ml of normal saline IV, Group S received 5ml of normal saline IV, immediately prior to the induction of general anesthesia. Observation for nausea, vomiting and retching were carried out at 0- 2 h and 2- 24 h postoperatively. Nausea was recorded on 0 to 10 rating (VAS score). Score 0= no nausea, 1-3= mild nausea, 4-6=moderate nausea, 7-10 =severe nausea. Results: The incidence of nausea and vomiting was significantly less in Group M and Group O as compared to Group Conclusion: Our study showed that IV midazolam and ondansetron provides significant reduction in nausea and vomiting in patients undergoing middle ear surgery.
