Introduction: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease was first identified in December 2019 in Wuhan, the capital of China's Hubei province, and has since spread globally, resulting in the ongoing2019-20 coronavirus pandemic. As of 4 May 2020, more than 3.5 million cases have been reported across 187 countries and territories, resulting in more than 247,000 deaths. More than 1.12 million people have recovered.Common symptoms include fever, cough, fatigue, shortness of breath and loss of smell and taste. Aim: This study is to study thesiddha prospective aspect of immune booster against COVID – 19to follow the seasonal regimen (ruthu sariyai). Results and Discussion: In Siddha, the year is divided into six seasons consisting of two months each. The regular disciplines of food and action are mentioned for each season in Siddha text. This COVID -19 infection hitted periods are Munpani, Pinpani, Ilavenil and Mudhuvenil. There is no specific medicine to treat coronavirus disease (COVID-19). Therefore, we must enhance our immunity. In Siddha, Various foods and seasonal regimens are mentioned in Siddha authentic literatures to boost the immunity. Mentioned seasonal regimens are validated in this study. The regular disciplines of food and action as mentioned for each season are followed as strictly as possible so that we could avoid the occurrences of the COVID - 19.Conclusion: According to the results and discussion of this research seasonal variations altered the body functions. Therefore, our immune system become affected. Its regulation regimen has been mentioned in Siddha medicine. In this seasonal variation affected to body and mind therefore, Siddhars already defined the diet and habits on particular season. This research provides useful documentation in seasonal regimen to healthier living.