Background: Down syndrome is one of the most common genetic causes of developmental delays. Children with Down syndrome exhibit a reduction in bone mineral density. Objective: To systematically review the available studies on the effectiveness of whole-body vibration on bone density in children with Down syndrome. Methods: Four electronic databases; PubMed, Cochrane Library, Physiotherapy Evidence Database (PEDro), and Google Scholar were searched up to June 2019. Studies were selected if they were published full text randomized controlled trails in peer-reviewed journals in any language and focused on the effect of whole-body vibration for children with Down syndrome who aged one to 18 years. The outcome measure was bone mineral density. Two authors independently screened articles, extracted data and assessed the methodological quality using PEDro scale, with revision from the first author. Modified Sackett Scale was used to determine the level of evidence for the outcome. Results: Out of 540 articles screened, two studies with 55participants met the inclusion criteria. The duration of treatment ranged from 10 to 20 minutes, three times a week and for 12–20 weeks. One study has a fair quality, while the other has poor quality (with a mean Pedro score of 3.5 out of 10).The clinical homogeneity of studies makes meta-analysis appropriate. The mean difference across all studies is -0.43 (95% CI is -0.98- 0.11). According to Modified Sackett Scale, there is level 2 evidence to support using whole body vibration for increasing bone mineral density. Conclusion: In children with Down syndrome, there is poor-quality evidence that whole body vibration training improves bone mineral density. Therefore, high-quality studies are required.
