There is a vast time approach evolution in medication and there preparation methods which has brought into medicines which are even more effective and target the specific cells and not the entire body and produce more biological effect rather than producing adverse effects one of these is liposomal vesicles which has been evolve over time. Vesicular systems are highly ordered single or multiple assemblies Bilayer of concentrated lipids. Nonetheless, its physicochemical possessions such as sedimentation, hydrolysis, and oxidation, as well asstowingcircumstances have been restricted the consumption of liposomes. The soft gelatin-based capsules containing proliposomes of DCT were prepared using film deposition on carrier method.6 different formulations were prepared with varying concentrations of DCT and phospholipids. Particle Size, PDI and zeta potential of the formulations is given in table 2. The particle size was in the range of 212 ± 12 to 414 ± 18.3 nm following hydration of proliposomal formulations in 0.1 M HCl to obtained simulated conditions of gastric fluid. Liposomes usually have biphasic release pattern. A rapid release is observed in the first phase followed by a relatively slower and sluggish release that is usually sustained type for 12 h or more. The initial rapid release may be associated with the erosion of the outer surface due to presence of no entrapped drug there.
