The COVID-19 pandemic, also known as the coronavirus pandemic, is an ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The outbreak hit the world with unprecedented consequences on global health, economy and people’s lives. Going to work during this pandemic has placed frontline workers under immense and unprecedented pressure, putting their physical, mental and social well-being at risk. Exposure to excessive stress, for prolonged periods can have many harmful consequences on the emotional and mental well-being of frontline workers.The objective of this paper is to explore the challenges faced by the frontline workers (doctors, nurses and community health workers) during COVID 19 in different countries across the world.The literature search analyzed only peer-reviewed papers associated with challenges faced by frontline workers during COVID 19 pandemic across the globe.This study reports on the psycho-social health and well-being of front line health workers during this pandemic. It is important that employers and organisations recognise the challenges this vital workforce face in times of pandemics and implement appropriate support for these workers.