A review on the effect of sulphur mustard on gene expression alterations, finding the most important molecular functions using gene set functional enrichment analysis
Background: Sulphur mustard (SM) is a very reactive agent and causes severe chemical burns. In addition to various cellular and molecular damages, SM affects the expression of several genes. The main aim of this study was to review SM-induced gene expression alterations. Furthermore, using enrichment analysis, we tried to identify the most important molecular functions involved in the occurrence of SM injury, based on the found gene sets. Methods: With the aim of finding genes associated with SM-induced injuries, the literature was reviewed and data were collected manually.