Background and Objectives: There are several life threatening deadly diseases in our world but 'Depression' out power them all in recent years. It is a nightmare now a days that could destroy a whereby strong and healthy person emotionally, mentally and physically in days to month's time. The discovery of selective serotonin receptor antagonist act as a miracle in the treating depression as it greatly reduces the time for therapeutic outcome but also improve the efficacy. The present study was designed to observe the effects of citalopram on gastrointestinal smooth muscles in vitro. Method: Contractile response of acetylcholine, serotonin & citalopram on isolated rabbits ileum was recorded on power lab USA. Results: The percent responses with acetylcholine, serotonin and citalopram were 100, 140 and 5.45 percent respectively indicating that citalopram has a depressant effect on motility. Conclusion: Inability of paroxetine to enhance the serotonergic transmission in vitro causes a decrease in its qualitative response.
