The Employees’ State Insurance Scheme as per the ESI Act provides social protection to employees in the organized sector and their dependents. This study mainly conducted to analyse the effectiveness of awareness on ESI scheme on satisfaction of employees enrolled in ESI scheme in Kerala. The effect of awareness about ESI scheme on employees’ satisfaction towards ESI scheme is explored by structural equation model. There is a significant impact on the employees of all ESIC regions in Kerala as they are more aware and satisfied about the benefits of ESI scheme. Awareness about cash benefits and medical benefits are main influencing factors on the awareness about ESI scheme. Confirmatory factor analysis asserts that satisfaction on the services provided by the ESI hospitals and the sense of social security are the major contributing factors for raising the level of satisfaction of employees towards ESI scheme. Though awareness on ESI schemes has pointed a positive effect on satisfaction level, more efforts are needed. This gap can be compensated by conducting various awareness programs and promotional activities regarding the scheme.