Purpose of the study: To investigate the effect of mirror therapy on Complex Regional Pain Syndrome (CRPS) post wrist burn. Methods: Thirty patients were randomly divided into two equal groups; Group A (study group) and Group B (control group). Group (A) received conventional hand progressive exercise program (active, and active resisted hand exercises)in addition, the same exercises were done by the sound hand in front of mirror for 15 min in the first 2 weeks and 30 min in the last 2 weeks. Group (B) received only conventional hand progressive exercise program. The total duration of treatment was four weeks (30 min, 3 sessions per week). Methods of assessment included visual analogue scale (VAS) to assess pain and hand held dynamometer to assess hand grip and pinch, pretreatment and post treatment (after four weeks). Results: The results showed a significant improvement in VAS and hand grip as the percentage of improvement of VAS in groups A and B was 58.65% and 33.9% respectively, while in hand grip strength was 39.55% and 16.36% respectively. However, there was a significant improvement in VAS and hand grip in group A compared to group B (P=0.001), also we reported a significance increase in pinch strength as the percentage of improvement in groups A and B was 75.16% and 33.56% respectively with more significant improvement in group A compared to group B (P=0.0001). Conclusion: From the finding of the current study we concluded that mirror therapy exercise program is an effective, safe, relatively inexpensive, simple and available modality in decreasing pain and improving function level.