Incretins are the types of metabolic hormones responsible for reducing blood glucose. The two naturally occurring incretins are glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). They are responsible for amplification of response of insulin to enteral entry of glucose in the body. DPP 4 are the enzymes responsible for the degradation of incretins. This incretin effect is the newer approach to treatment of diabetes. The two groups acting through this pathway are GLP 1 agonist and the DPP 4 inhibitors.
Paper No:
1812
