Grave´s disease (GD) is an autoimmune disorder characterized by the presence of autoantibodies that bind to the thyrotropin receptor (TR) in the gland, leading to excess production of thyroid hormones maintaining a state of hyperthyroidism. Also this autoantibodies recognize the TR present on orbital fibroblasts, which produce the tissue changes of Grave´s ophthalmopathy (GO): eyelid retraction and swelling, proptosis, orbital congestion (chemosis), exposure keratopathy, extraocular motility dysfunction, as well as compressive optic neuropathy in more severe cases. The case of a 14-years-old patient with bilateral proptosis is presented.
Paper No:
3408
