A placebo controlled study of prophylactic anti emetic effects of midazolam and ondansetron for preventing post operative nausea and vomiting in middle ear surgery

The present study evaluated the antiemetic effects of midazolam an ondansetron for preventing post operative nausea and vomiting in middle ear surgeries. Material and Mehods: After attaining approval by ethical committee of the institute, 105 patients were randomly divided into three groups (35 patients of ASA I and II physical status in each group). Group M received 0.05mg/kg of midazolam diluted in 5 ml of normal saline IV, Group O received 0.15mg/kg of ondansetron diluted in 5 ml of normal saline IV, Group S received 5ml of normal saline IV, immediately prior to the induction of general anesthesia. Observation for nausea, vomiting and retching were carried out at 0- 2 h and 2- 24 h postoperatively. Nausea was recorded on 0 to 10 rating (VAS score). Score 0= no nausea, 1-3= mild nausea, 4-6=moderate nausea, 7-10 =severe nausea. Results: The incidence of nausea and vomiting was significantly less in Group M and Group O as compared to Group Conclusion: Our study showed that IV midazolam and ondansetron provides significant reduction in nausea and vomiting in patients undergoing middle ear surgery.