A rare case report of cutaneous hybrid cyst from India, is it telling us something?

Many types of the cutaneous hybrid cysts are described in literature since they were first described in nineteen sixties. These hybrid cysts are developing from Folliculo-sebaceous apocrine units in the skin. These can be single or multiple. When such type of cyst is detected, these patients are frequently examined for any syndromic association like Lowe syndrome, Gardner syndrome and Gorlin Goltz syndrome. However, literature shows that many of the cases are non-syndromic. There can differentiation towards infundibulum, isthmic region or lower parts like follicular matrix, inner root sheath and hair. Exact pathogenesis involved in the formation of these cysts is largely unknown. Follicular germinative cells are hypothesized to form these types of cysts which are capable of divergent differentiation. There are occasional case reports from India. Hereby we report rare case of cutaneous hybrid cyst in middle aged male with right forearm swelling for 8 months. On histopathological examination lesion, it showed epidermal inclusion cyst and Pilomatricoma. The patient was asymptomatic apart from the swelling. He had no gastro-intestinal problems and his family history was negative for the colorectal carcinoma.