Abnormalities of Liver Enzymes are common in Human immunodeficiency virus (HIV). Infected patients. Hepatic injury due to HIV leading to an increase in the Hepatic Enzymes (ALT, AST, ALP). Elevations in the liver enzymes signals injury to the liver cells and in some cases to other cells in the body. The activity of liver enzymes in 100 patients, aged 20-50 years, with HIV Seropositive infection was assessed and 50 age matched apparently healthy subjects tested negative for antibodies for HIV 1 and 2 sereved as control. The activities of Serum alanine amino transferase (ALT) and Serum aspartate aminotransferse (AST) were observed significantly higher in HIV infected patients than those to the reference group. There is no significant difference observed in serum alkaline phosphatase (ALP) of HIV infected when compared to control subjects. Increase in ALT and AST is most likely due to impairment or involvement of the liver in HIV infection.
