Background: Acute Myocardial Infarction (AMI) has become one of the major causes of mortality in the world at present, and it is for this reason various researches are being done for its diagnosis and prognostic assessment. Serum enzyme estimation is an important tool for it. Aim: To study changes in serum cardiac markers, after acute attack of MI Before & 2 hours after reperfusion and to establish usefulness of enzymes in early diagnosis of AMI. Methodology: A study of changes in serum cardiac markers CK-MB, LDH and AST, after acute attack of MI-before and 2 hours after reperfusion was conducted at govt. hospital. Total 100 patients were studied. All the patients were confirmed cases of AMI, admitted in the intensive care unit of Government General Hospital, Rajiv Gandhi Institute of Medical Sciences, Kadapa. Blood samples were collected in plain bulb, at the time of admission and at 90 minutes (i.e. after reperfusion) and enzyme estimation was done for all 3 enzymes. Result: It was found that the serum CK-MB is the first and earliest enzyme released in compare to AST and LDH, and after reperfusion it increases 6-7 folds. The mean levels of all enzymes were higher after reperfusion, suggestive of good prognosis in case of early reperfusion after an attack of AMI.
