We report a case of a 51-year-old male with controlled hypertension and recent severe COVID-19 infection treated with high-dose steroids, Bevacizumab, and Remdesvir, presenting with black tarry stools, upper abdominal pain, and paleness, with laboratory findings showing severe anemia (hemoglobin 5.6 g/dL) and liver lesions, upper gastrointestinal endoscopy revealed a large excavating ulcer from the fundus to the antrum, aspirate culture confirmed Mucor spp., leading to a diagnosis of gastric mucormycosis, treated with intravenous liposomal amphotericin B followed by posaconazole, and a conservative approach was taken due to high surgical morbidity, with significant clinical improvement over three months, highlighting the importance of early diagnosis and antifungal therapy in immunocompromised patients.
