Background: Most men diagnosed with prostate cancer (PCa) their age are 50 or older treated by androgen deprivation therapy (ADT) treatment has been associated with interconnected adverse effects as decreased bone mineral density (BMD) and a loss in the structure and strength of bone leading to osteoporosis. Exercise has been proposed as a treatment to relieve adverse effects of ADT. Objective: This study was conducted to evaluate the effect aerobic exercises versus resisted exercises on osteoporosis in prostate cancer patients undergoing androgen deprivation therapy. Methods: Thirty prostate cancer patients suffering from osteoporosis after receiving androgen deprivation therapy,were selected from Oncology department at El Galaa Hospital for Armed Forces. Their age ranged from 50 to 65 years and were subdivided randomly into two equal groups. Group A (Aerobic exercises group): This group included 15 PCa patients who received aerobic exercises in the form of cycling on electronic bio in addition to conventional medical care (Calcium and vit D supplements), 3 days per week for 12 consecutive weeks. Group B (Resisted training group): This group included 15 PCa patients who received resistance exercises for both lower limbs (hip flexors, abductors and knee flexors, extensors) by free sand bags of different weights in addition to conventional medical care (Calcium and vit D supplements), 3 days per week for 12 consecutive weeks. Dual-energy x-ray absorptiometry (DEXA) was used for estimation of BMD before the treatment and after 12 weeks of treatment for both groups. Results: The study showed that there was a statistically significant increase in BMD and T-score mean of spine, femoral neck and total femur post treatment in the resistance exercise group compared to aerobic exercise group, The percent of increase in BMD of spine, left femoral neck and total femur in the group A was 26.02, 18.9 and 19.47% respectively, while that in the group B was 39.55, 41.33 and 39.94% respectively. Conclusion: It can be concluded that both aerobic and resistance exercises had fruitful effects in cases of osteoporosis in prostate cancer patients receiving ADT as evidenced by the significant increase in BMD and T-score mean, however higher statistical improvement was reported in the resistance exercise.
