Background: With the advancements of health sector around the world, this study aims to compile the different genetic diseases present in Quirino and Isabela province in the Philippines in order to provide a knowledge to the community and prevent this genetic disorder in the future. Objectives: The objective of this research is to know the common genetic disorder present in the province of Isabela and Quirino, Philippines. Methods: The researcher use mixed methods of secondary data analysis or archival study and selective interview. The researcher saw that these methods fit because the researcher be requesting, from two random Rural Health Units (selected through fishbowl technique) per province in the region, a copy of their database or sheet on the genetic disorder cases in their places. Afterward, a structured interview will be administered to gather other necessary information that is not answered through the datasheet given. Results: There are 277 recorded cases of genetic diseases and disorders here in the region. 81 of which are acquired and 196 are inherited. Of the 277 cases, 166 are from Isabela and the remaining are from 111 Quirino. The number one case in Isabela is diabetes and learning disability from Quirino. When the data from the two provinces are combined, the highest case goes to cleft palate which is also the top 2 numerous cases of Isabela and top 3 of Quirino. Conclusions: This growing number of cases are mainly due to the lack of funding and shortage of geneticists in our country. Another contributory part is the lack of knowledge on prenatal care of some parents in the region. Unfortunately, some of them conceived a child with genetic alteration because of one of the following: Improper medication (hilot), Menopausal baby, Parents are both cousin, Unhealthy work environment, Lack of nutrition
