Studies are needed to determine how fasting in humans improves health. Is it a simple replenishment of risk factors related to hypercholesterolemia, smoking, hypertension, hyperglycemia, mediated exfoliation of endothelial cells. Irrespective of the mechanism involved, the current study aims to study the significance of Ekadashi Upavasa with relevance to its wider philosophical, spiritual and physiological aspects. The current descriptive research is qualitative in nature and it recounts the historical evolution of Ekadashi Upavasa and critically analyzing its current medical applications, including benefits and caveats. The current study reveals that fasting on Ekadashi not only holds religious significance but also provides various benefits for our overall well-being through physical, spiritual and mental advantages of detoxification, improved digestion, weight-management, deepening-devotion, seeking divine-blessings, increased mental-clarity, self-awareness, emotional balance, and strengthened willpower. Finally, Ekadashi Upavasa appears to have significant physiological and psychological benefits. The study provides scientific validation for this traditional fasting practice and encourages its inclusion in holistic health strategies; incorporating Ekadashi Upavasa as a regular practice can deepen one's connection to spirituality, strengthen community bonds, and contribute to personal and collective growth.
