Background: Lamb-Shaffer is a rare genetic syndrome with just 113 reported cases caused by SOX5 gene haploinsufficiency and disrupts the normal development of cartilage and the nervous system. It can cause an array of clinical features, including craniofacial abnormalities, intellectual disability, global developmental delay, ophthalmological abnormalities, and lesser-known behavioural disturbances. is a case report of ADHD and DMDD in Lamb-Shaffer syndrome, its presentation, and management. Case Report: A 7-year-old male patient presented to the clinic with hyperactivity and difficulty learning. He had a history of motor and language milestone delay, which led to genetic testing, and he was ultimately diagnosed with Lamb-Shaffer syndrome 2 years ago. The patient went to special needs school and had early access to physical, occupational, and speech therapies along with multiple trials of stimulant and non-stimulant medications, which led to adverse effects and failed to effectively help with behavioural and academic challenges. Neuropsychological assessment revealed significant cognitive impairment with a full-scale IQ of 57. The patient was ultimately diagnosed with disruptive mood dysregulation disorder (DMDD) and attention deficit hyperactivity disorder (ADHD), co-existing with Lamb-Shaffer syndrome. Treatment modifications included adjusting Viloxazine, introducing Clonidine, and planning to initiate Aripiprazole, alongside GeneSight genetic testing to optimize medication management. Conclusion: Management of Lamb-Shaffer is complex, especially with behavioural co-morbidities, and requires a multi-disciplinary approach. In our case, the patient failed multiple stimulant and non-stimulant medications, which prompts the importance of more longitudinal and long-term research for Lamb-Shaffer syndrome and behavioural co-morbidities and a need for individualized treatment.
September 2025
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Journal Area:ABSTRACT:Pub. Date: September 30, 2025Paper No:5869
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In the context of deepening globalization, China, as an ancient cultural country with a long history, has become one of the important factors attracting international students from all over the world. Sichuan cuisine, with its unique flavor of spicy and fragrant, enjoys a high reputation at home and abroad, and has become one of the largest cuisines in Chinese folk. However, international students in China (ISIC) encounter numerous challenges in adapting to and identifying with Sichuan cuisine food culture. This paper employs a questionnaire survey method to find that there are the following problems in the perception and identification of Sichuan cuisine food culture among ISIC, including a low acceptance of Sichuan cuisine ingredients, difficulty in adjusting to the numb and spicy flavors, and personal adaptation difficulties stemming from cultural disparities. This paper proposes suggestions aimed at effectively enhancing the acceptance and sense of identity of ISIC towards Sichuan cuisine food culture, thereby fostering the international dissemination of Sichuan cuisine food culture, bolstering cultural self-confidence and national pride, attracting more international students to study in China, and facilitating global food culture exchanges and mutual learning.
Pub. Date: September 30, 2025Paper No:6078 -
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This paper discusses the Software Defined Radio-based Digital Transceiver, focusing on the 256-QAM transceiver used exclusively in 5G. The transceiver discussed here is software-defined, quite unlike that used in 5G.The 5G transceiver switches to the 256-QAM Modulation scheme when the received power is high. This paper uses the SIMULINK model to discuss the 256-QAM Modulation scheme, where the whole transceiver is designed and implemented on an FPGA. The speed and reconfigurability of the FPGAs are the driving forces for such an implementation. This Model's VHDL and C codes are generated automatically using the HDL workflow advisor. This circuit was designed and implemented on ZEDBOARD, which has an SoC comprising the Zync-7000 FPGA and ARM processor. The whole Model runs such that a part runs on the FPGA, and the rest runs on the ARM processor.
Pub. Date: September 30, 2025Paper No:6108 -
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Studies are needed to determine how fasting in humans improves health. Is it a simple replenishment of risk factors related to hypercholesterolemia, smoking, hypertension, hyperglycemia, mediated exfoliation of endothelial cells. Irrespective of the mechanism involved, the current study aims to study the significance of Ekadashi Upavasa with relevance to its wider philosophical, spiritual and physiological aspects. The current descriptive research is qualitative in nature and it recounts the historical evolution of Ekadashi Upavasa and critically analyzing its current medical applications, including benefits and caveats. The current study reveals that fasting on Ekadashi not only holds religious significance but also provides various benefits for our overall well-being through physical, spiritual and mental advantages of detoxification, improved digestion, weight-management, deepening-devotion, seeking divine-blessings, increased mental-clarity, self-awareness, emotional balance, and strengthened willpower. Finally, Ekadashi Upavasa appears to have significant physiological and psychological benefits. The study provides scientific validation for this traditional fasting practice and encourages its inclusion in holistic health strategies; incorporating Ekadashi Upavasa as a regular practice can deepen one's connection to spirituality, strengthen community bonds, and contribute to personal and collective growth.
Pub. Date: September 30, 2025Paper No:6114 -
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Many students suffer from heavy stress when it comes to their exams, often disabling them from performing their best due to a fear of failure. This is significant because it affects one’s health, grades, and future endeavors. But how does exam stress affect students’ exam performance? Our objective is to decipher which physiological indicators affect the exam score the most. This study investigates whether physiological signals captured by wearables—electrodermal activity (EDA), heart rate (HR), blood volume pulse (BVP), skin surface temperature (ST), inter-beat interval (IBI), and accelerometer (ACC) data—can predict exam scores for three testing events (Midterm 1, Midterm 2, Final). To assess this, we used signal processing and feature importance in measuring and predicting the exam performance. I found that the feature that affected exam scores the most was the BVP readings, also known as the Blood volume pulse amplitude, had an importance of 0.068433.
Pub. Date: September 30, 2025Paper No:6134 -
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The present study aimed to develop and evaluate sustained release formulations of Lansoprazole capsules using solid dispersion and formalin-treated gelatin capsules to enhance solubility and achieve controlled drug delivery. Preformulation studies, including organoleptic characterization, solubility testing, and FTIR analysis, confirmed the drug’s poor aqueous solubility, stability, and compatibility with selected excipients. Solid dispersions were prepared by solvent evaporation employing hydrophilic polymers (PVP K30, PEG 6000, and Poloxamer 407) in varying ratios, which significantly improved dissolution behavior. Formalin-treated gelatin capsules were designed to modulate capsule solubility and delay initial drug release. Final sustained release formulations incorporated hydroxypropyl methylcellulose (HPMC, grades 4K and 100K) and sodium CMC as release modifiers. Physicochemical evaluation showed uniform weight, acceptable assay values, and intact capsule structure. In-vitro dissolution studies revealed extended drug release with polymer- and treatment-dependent variations. Formulations containing high-viscosity HPMC exhibited superior release control, fitting well to zero-order, Higuchi, and Korsmeyer–Peppas kinetic models, indicating a predominantly diffusion-controlled mechanism. FTIR confirmed the absence of drug–excipient interactions, ensuring formulation stability. Overall, the study demonstrates that combining solid dispersion with formalin-treated gelatin capsules is a promising approach for improving solubility and sustaining the release of Lansoprazole, thereby potentially enhancing therapeutic efficacy, reducing dosing frequency, and improving patient compliance in acid-related disorders.
Pub. Date: September 30, 2025Paper No:6135 -
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Different thiazolidine derivatives were synthesized in this work. Thiazolidinemotifs are highly interesting heterocyclic five-membered moieties that are found in a variety of natural and bioactive compounds. They have nitrogen at the third position and sulfur at the first. Is a five-membered ring that contains one atom each of nitrogen and sulfur. It has also been discovered that hydrazides and their hetrocyclized derivatives play a significant part in biological processes. They are employed as vehicles in the synthesis of valuable organic combinations because the presence of sulfur improves their pharmacological characteristics. The newly synthesized compounds were analyzed using IR, 1H-NMR, and 13C-NMR spectral analysis. The presence of an azo moiety also increases data.
Pub. Date: September 30, 2025Paper No:6147 -
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Water is a fundamental carrier of life and energy, and its structural and vibrational properties are increasingly recognized as essential indicators of quality. This study explores water collected from the Ravne Tunnel Complex in Visoko, Bosnia-Herzegovina, a site associated with the Bosnian Pyramid structures. Through a combination of standard laboratory analysis and advanced holistic techniques, we investigate the physical purity, mineral content, and energetic characteristics of this unique subterranean water. Conventional analysis revealed no microbial contamination, a stable pH of approximately 7.45, and the presence of beneficial minerals, with no detectable toxins. Complementary investigations, including spagyric crystallization imaging (Life Vision Lab), Emoto-style ice crystal photography, and Bovis scale radiesthetic evaluation, revealed a high degree of molecular coherence and elevated vibrational frequency. Comparative samples from municipal sources lacked these qualities. The findings suggest that Ravne water, exposed over time to a high concentration of negative ions and possible pyramid-induced energy fields, exhibits characteristics of highly structured, bioenergetically vital water. This multidisciplinary approach introduces a novel perspective on the nature of water and offers a promising foundation for further inquiry into energetically enhanced hydration.
Pub. Date: September 30, 2025Paper No:6044 -
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This study reports the use of tumescent local anesthesia (TLA) in a bitch undergoing unilateral mastectomy, aiming to evaluate its analgesic efficacy and trans- and postoperative safety. The patient, a mixed-breed female, underwent ovariohysterectomy and excision of the right mammary chain. The tumescent solution consisted of 2% lidocaine, epinephrine, and cooled Ringer’s lactate, administered at a dose of 15 ml/kg. The surgery lasted 2h20min, with hemodynamic stability and effective pain control. Recovery was satisfactory, with appropriate healing and positive clinical outcome. It is concluded that TLA is a safe, effective, and feasible complementary method for extensive procedures.
Pub. Date: September 30, 2025Paper No:6159 -
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La recherche sur terrain nous a permis de se pencher sur les méthodes et les outils utilisés pour décrire en détail. Leurs contextes ainsi que les facteurs favorables et défavorables ont été pris en compte dans la mesure du possible et leurs réussites et l’impact sur la réduction de lutte contre la corruption. Et pourtant la corruption fait d’avantage mal dans les milieux scolaires. Que peut-on tirer des élèves qu’àon a appris à corrompre ? Que deviendront demains ces enfants qui ont appris à réussir sans effort et qui n’appartiennent finalement rien, sinon la façon de passer de classes en donnant quelques faveurs à l’enseignants ? Que feront finalement ces enfants dans leur milieu professionnel ? Vont-ils continuer à corrompre pour bien dresser un rapport, construire un pont, gérer le personnel ? Cette recherche s’inscrit dans cette dynamique de travaux cherchant à comprendre et à expliquer certaines conduites corruptives et comment lutter contre ce fléau auprès des enseignants éducateurs vis-à- vis de la pratique de la corruption dans leur milieu scolaire.
Pub. Date: September 30, 2025Paper No:6085 -
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The present study of Dicoma tomentosa has been discussed with their habit, habitat, flowering & fruiting, taxonomic enumeration, nativity and physiographic position. The floristic account reveals that occasional threatened distribution of this species found few districts of Uttar Pradesh and dealing as becomes vulnerable species. The specimen deposition of this species which assist its future purpose.
Pub. Date: September 30, 2025Paper No:6136 -
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L’intelligence artificielle (IA) est un ensemble de théories et de techniques visant à réaliser des machines capables de simuler l’intelligence humaine. Par extension, dans le langage courant, l’IA inclut les dispositifs imitant ou remplaçant l’homme dans certaines mises en œuvre de ses fonctions cognitives. L’intelligence artificielle est utilisée dans de nombreux domaines. Ses capacités permettent notamment d'automatiser et d'optimiser des tâches complexes et complémentaires, de traiter et d'analyser de vastes quantités de données, et d'améliorer la prise de décision. Alors que l’intelligence artificielle s’invite progressivement dans le fonctionnement d’une multitude d’activités dans plusieurs pays du monde entier, un pays comme la Côte d’Ivoire doit se l’approprier dans divers de ses domaines d’activités, particulièrement dans la conservation du patrimoine audiovisuel et de la promotion culturelle. Ce faisant, le monde des archives et du patrimoine documentaire ivoirien doit s’intéresser ainsi à l’IA pour traiter des films anciens avec l’apport de cette technologie. Car en effet, l’intelligence artificielle a de fructueux apports à la recherche archivistique. Dans l'ensemble, l'utilisation de l'IA dans l'archivistique en Côte d’Ivoire doit être guidée par des principes éthiques solides, en veillant à ce que les avantages de l'automatisation soient équilibrés avec la protection des droits des individus et des organisations.
Pub. Date: September 30, 2025Paper No:6142 -
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Humanity is facing new weather phenomena. This is explained by the greenhouse effect and the increase in carbon dioxide. However, there are considerable doubts about this simplified, monocausal hypothesis. The history of warm and ice ages is not taken into account, nor are cyclical processes in the solar system. Therefore, the enormously expensive fight against CO² is pointless and will be unsuccessful. Plants need CO², therefore, we should build greenhouses. We should take meaningful and inexpensive measures which are presented here.
Pub. Date: September 30, 2025Paper No:6166 -
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This study examines the role of employee participation in organizational development, focusing on attitude, productivity, and growth. The concept of Workers' Participation in Management (WPM) has evolved through legislative measures, including the Industrial Disputes Act 1947 and the 42nd amendment to the Indian Constitution, which added Article 43(a) promoting worker involvement in industry management. Despite legislative efforts, employers often fail to positively respond to worker participation. This study aims to understand the level of employee participation and satisfaction in decision-making processes within Pratibha Patil Sugar industries pvt Ltd, Kannur, Vijayapura, Karnataka. Data was collected from 100 laborers using random sampling and an interview schedule. The analysis focuses on employee perceptions and suggestions for organizational development. A significant 70% of employees suggest that increasing opportunities and improving coordination are crucial for supportive organizational development. This study highlights the need for effective employee participation in driving organizational growth and productivity.
Pub. Date: September 30, 2025Paper No:6182 -
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This study explores the skill readiness of prospective teachers in B.Ed colleges of Vijayapur city with reference to Education 4.0 competencies. Using pre- and post-test assessment design, the research measured trainees’ achievement scores across eight skill domains: cognitive flexibility, complex problem solving, creativity, critical thinking, decision making, emotional intelligence, negotiation, and time management. Percentage analysis revealed that while the majority of trainees fell within the average category in the pre-test, significant improvements were observed in post-test scores, particularly in critical thinking, creativity, and problem-solving. The study provides evidence-based recommendations for enhancing teacher education curricula to align with Education 4.0 demands.
Pub. Date: September 30, 2025Paper No:6148 -
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We present a method for the evaluation of the capacitance and charge distribution between the metallic truncated cone of finite length with bottom and the grounded metallic plate. The estimation of capacitance and charge distribution is carried out using the method of moments (MoM) based on pulse function as the basis function and point matching for testing. The matrix elements to be inverted in the solving process are found by dividing the surfaces of the truncated cone and the metallic plate into subsections. The capacitance and the charge distribution are derived from the inverse matrix. Numerical results on the capacitance and charge distribution between the metallic truncated cone of finite length with bottom and the grounded metallic plate are compared with the experimental data.
Pub. Date: September 30, 2025Paper No:6080 -
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En entreprenant cette recherche sur « le profil des agents de l’Etat affectés dans les services de planification de l’éducation des sous provinces éducationnelles de Kinshasa », nous avons voulu savoir si ces agents exercent vraiment le travail destiné aux planificateurs de l’éducation dans leurs services. Notre but était de vérifier les hypothèses suivantes : Les agents affectés dans les services de planification des sous provinces éducationnelles de Kinshasa n’auraient pas le profil nécessaire pour accomplir avec compétence le travail des planificateurs de l’éducation, et les agents affectés dans les services de planification des sous provinces éducationnelles de Kinshasa ne contribueraient pas réellement à projeter l’avenir en matière d’enseignement en utilisant les indicateurs appropriés pour éviter les improvisations. Après analyse et traitement des données, nous avons constaté que ces agents de l’Etat commis dans les services de planification de l’éducation des sous provinces éducationnelles de Kinshasa n’exercent pas totalement le vrai travail d’un planificateur de l’éducation.
Pub. Date: September 30, 2025Paper No:6088 -
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This paper explores how technology can be leveraged to create and improve awareness of nutrition in developing contexts. It highlights the coexistence of undernutrition, micronutrient deficiencies, and diet-related chronic diseases, stressing the need for effective communication and education to promote healthy diets. Case studies such as local production of Plumpy’nut in Tanzania, D-Tree International’s mobile diagnostic tools, and Living Goods’ nutrition-based social business model demonstrate how technological innovations and mobile platforms can enhance access to therapeutic foods, improve clinical care, and disseminate nutrition messages at the community level. The discussion emphasizes three critical responsibilities for nutrition programs: mobilizing resources, implementing communication strategies, and strengthening human resource capacity for effective nutrition education. Challenges such as limited funding, inadequate training in communication, and resource allocation are addressed, with recommendations for systematic planning and prioritization of communication in health programs. In conclusion, technology-driven approaches ranging from mobile apps to social enterprises offer scalable solutions to improve nutrition awareness and outcomes. By integrating communication strategies with resource mobilization and evaluation, nutrition programs can achieve greater impact in promoting public health and wellbeing.
Pub. Date: September 30, 2025Paper No:6478