This study reports the use of tumescent local anesthesia (TLA) in a bitch undergoing unilateral mastectomy, aiming to evaluate its analgesic efficacy and trans- and postoperative safety. The patient, a mixed-breed female, underwent ovariohysterectomy and excision of the right mammary chain. The tumescent solution consisted of 2% lidocaine, epinephrine, and cooled Ringer’s lactate, administered at a dose of 15 ml/kg. The surgery lasted 2h20min, with hemodynamic stability and effective pain control. Recovery was satisfactory, with appropriate healing and positive clinical outcome. It is concluded that TLA is a safe, effective, and feasible complementary method for extensive procedures.