Ayurveda, the ancient science of life, emphasizes the harmonious interaction between body, senses, mind, and soul. The concepts of Trividha Hetu (three fundamental causes of disease) Asatmya Indriyartha Samyoga (improper contact of senses with their objects), Prajnaparadha (intellectual blasphemy), and Parinama (time effect) and Asatmya Indriyartha Samyoga (improper connection of the sense organs with their objects) collectively explain the etiological and preventive aspects of health and disease. Among these, Rasanendriya (organ of taste) holds special significance in maintaining physiological and psychological balance. In today’s fast-paced world, irregular food habits, overconsumption of processed and flavoured foods, and emotional eating have distorted the natural Rasanendriya Samyoga, leading to lifestyle disorders such as obesity, diabetes, hypertension, and depression. This paper critically examines the classical Ayurvedic principles of Trividha Hetu and Asatmya Indriyartha Samyoga, particularly with reference to Rasanendriya, and correlates them with modern dietary behaviour. Through literary review and comparative analysis, it highlights how improper sensory use contributes to disease, and how restoring Satmya Samyoga through mindful and balanced eating offers a holistic preventive approach in modern times.