The present research article reviews a systematic study on the effects of cold-water exposure on human health on the basis of thermodynamics and hydrostatic pressure. Literature review suggests that repeated cold-water immersion on the human body is associated with boosting the immunity. Through rapid heat transfer and hydrostatic pressure–mediated circulatory shifts, cold-water immersion activates thermoregulatory and stress-adaptation pathways that are responsible for metabolic efficiency, and immune function. Accordingly, controlled cold-water exposure may serve as a cost-effective and sustainable non-pharmacological intervention to strengthen immune resilience.