The current rapid deterioration of air quality in most cities can be attributed mainly to ongoing urbanization. This study simulates the dispersion of atmospheric pollutants in the city of Bamako using a HYSPLIT model, taking into account a case of total suspended particulate (TSP) emission in the environment assumed to be 180μg / m3 which exceeds two times the WHO standards. Wind climatology was established using the Wind Rose Plot (WRPlot) view. The predominant wind speed on the city is 2 to 6 knots (1 to 4 m / s) and the wind direction is southwesterly with varying seasonal direction. The forward trajectory of a released pollutant in the city is generally observed to move towards the west side of the city. It is observed that the pollutant is dispersed beyond 100 km of the city, which reduces the concentration in the city. The study recommends a consultative planning process of the city that influences the characteristics of the wind on the city. Most industrial activities should be located in the extreme south of the city in order to minimize the concentration of pollutants in the city. The study further recommends that research be conducted over a longer period to determine the quality of rainwater during the rainy season. This requires accurate observation and monitoring of pollution levels in the city and other cities in the country.