Background: This retrospective study was conducted between 2017 and 2023 on 84 patients affected by gonalgia, which was clinically and radiologically documented. Objective: The aim was to assess the efficacy of manual therapy and myofibrolysis. Methods: Patients were assessed clinically and through radiographs, and range of motion (ROM) that was measured using a goniometer and pain level assessed via the VAS scale, both at baseline, 1-2, 3-8, and up to 10 months to 6 years’ post-treatment, were determined. Results: The patients enrolled (19 males, 65 females) aged between 16 and 90 years (mean age 65.8 years). Knee pain was more prevalent on the right side in 50 subjects while on the left in 34. The average number of treatments was 3.1 (ranging from 1 to 6). Radiological severity, according to the Kellgren-Laurence classification, ranged from 0 to 4. The average initial ROM was -31.3° (ranging from 0 to -60°), improving to -13.9° at 1-2 months, -10.1° at 3-8 months, and -8.5° at 10 months to 6 years. VAS score was 5.7 (ranging from 4 to 10), with significant reductions at 1-2 months (VAS mean 3), 3-8 months (VAS mean 2.1), and 10 months to 6 years (VAS mean 1.8). Conclusion: The results suggested that manual therapy combined with myofibrolysis can have a positive impact on improving ROM and reducing pain (VAS). This approach may also reduce the need for addition-al treatments, slow disease progression, and, in some cases, delay or avoid the need for joint replacement.
