Robust studies highlighted the valuable role of student-centered learning approach to acquire the full range of “life skills” among modern learners. Undeniably, the fact that the interaction in learning milieus are so diverse, hence, we need to examine available variables that may influence the validation of skill competencies obtained from learner-centered environment. Results of the study shows that age and religion are insignificant variables to influence the development of soft skill in student-centered approach. Males have better cognitive skills while females are more digitally literate. K12-strand particularly technical vocational is a factor to consider in cognitive development. Academic discipline is a variable that influence enhancement of communication and digital literacy. Pre-college student-centered learning teaching method is variable that affects cultivation of almost all life skills. The study confirmed the enhancement of 21stcentury soft skills: collaboration, digital literacy, communication, creativity, self-directed learning, cognitive, critical thinking skills in student-centered approach.