In order to determine the epidemiological profile of neonatal infection in Kindu, this retrospective study was conducted on 116 cases of neonatal infection recruited in neonatology from the general reference hospital of Kindu. The clinical picture was marked by the frequency of severe forms. The bacteriological assessment allowed the confirmation of neonatal infection in 92 cases and showed the predominance of gram-negative bacilli, streptococcus B and the absence of listeria monocytogenes.Neonatal infection remains a worrying pathology in terms of its frequency and severity. Its frequency is estimated at 10 to 15% of live births.The incidence of maternal-fetal infection is around 0.6% to 1% at birth. Its severity is linked to the immuno-incompetence of the newborn and to the risk of mortality which is around 10 to 30% depending on the series.Its diagnosis is of variable difficulty highlighting the importance of the paraclinical assessment, in particular the bacteriological samples. Treatment is based on antibiotic therapy adapted to the sensitivity of the responsible germs, based on 3rd generation cephalosporin, amino penicellin and aminoglycoside associated with symptomatic treatment.