MDR1 mRNA Expression by real time - pcr and relationship with clinical response before and after giving neoadjuvant chemotherapy regimen cyclophosphamid-doxorubicin-5fu cdf) in local advanced breast cancer labc)
Background: Chemoresistanceinvolving P-gp / MDR1 as uncertain factors affect the clinical response after the administration of neoadjuvant chemotherapy NAC) regimen Cyclophosphamid-Doxorubicin-5FU CDF). Response to chemotherapy can be assessed by changes in mRNA expression of MDR1 gene due to DNA damage in the cancer cell DNA synthesis by examination of quantitative Real Time PCR qRT-PCR). Objective: Knowing the direction of change in MDR1 mRNA expression before and after administration of NAC regimen CDF on Local advanced breast cancer LABC) based clinical response.