Ascertaining the effectiveness of learning management systems (LMSs)is of great importance for managers and policy makers in institutions of higher education to make investment decisions basing on evidence rather than rhetorical claims about the advantage of ICT. However, the effectiveness of ICT tools in teaching and learning has remained unclear with studies giving inconsistent findings. In this paper, we base on the De Lone and McLean’s (2003) information systems success model as our lens to propose a study on effectiveness of Makerere University E-Learning Environment (MUELE) as a specific ICT tool used in teaching and learning. We hence, propose six interdependent variables as measures of effectiveness of MUELE, namely, net benefits of MUELE, use of MUELE, user satisfaction with MUELE, quality of information uploaded on MUELE, quality of performance of MUELE and quality of technical support received by a user of MUELE. Weposit that the overall dependent variable are the net benefits of MUELE while both use of MUELE and user satisfaction with MUELE are intermediate variables. We also posit that quality of information uploaded on MUELE, quality of performance of MUELE and quality of technical support received by a user of MUELE are the dependent variables. In this paper we give an introduction to our proposed study, statement of the problem, our study objectives and significance, theoretical review, related literature, the hypotheses and methodology of our proposed study.