The Expression of cytoglobin (cygb) in hypoxia fibrosis tissue with keloid as a model
Cygb is an O2 carrier protein expressed by fibroblasts. In fibrosis, hypoxia occurs as characterized by stabilization of hypoxia-inducible factor-1α (HIF-1α), which later form the HIF-1, a transcription factor for the expression of adaptation proteins (including Cygb). The purpose of this study was to obtain information about Cygb role in fibrosis hypoxia using keloid tissue as a model. This was an observational descriptive study using keloid tissue samples, and the preputium as control. Measurement of Cygb and HIF-1α mRNA expression by real-time RT–PCR.